Analysis of p53 gene polymorphism (codon 72) in symptomatic patients with atherosclerosis
نویسندگان
چکیده
منابع مشابه
Analysis of p53 gene polymorphism (codon 72) in symptomatic patients with atherosclerosis.
Atherosclerosis is a multifactorial pathological disease that alters the morphology and function of arterial walls. The atheroma growth leads to vessel hardening and lumen narrowing, limiting the blood flow. The atheroma plaque can eventually break, expose highly thrombogenic material and lead to platelet activation and subsequent formation of a thrombus that may block blood flow in loco, or ev...
متن کاملP-93: Analysis of P53 Codon 72 Gene Polymorphism in Isfahanian Patients With Endometriosis
Background: The p53 tumor suppressor gene plays important roles in genomic stability. Several reports have noted racial differences in the prevalence of p53 genotypes at the codon 72 in patients with endometriosis.To study the association of endometriosis with p53 codon 72 polymorphism in the population of Isfahan. Materials and Methods: We undertook a case–control study to examine the possible...
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Background: Systemic lupus erythematosus is a systemic autoimmune disorder with unclear etiology. The importance of some genes in the development of systemic lupus erythematosus has been implicated. The gene polymorphism in codon 72 has attracted a lot of attention and its role in the occurrence or progression of many cancers and autoimmune diseases especially systemic lupus erythematosus has ...
متن کاملAnalysis of p53 codon 72 gene polymorphism in Brazilian patients with endometriosis.
We examined the frequency of p53 codon 72 polymorphism in 38 patients with endometriosis whose diagnosis was confirmed using videolaparoscopy. Half of the women were infertile. There were no significant differences in the genotype (P = 0.0927) or allele frequencies (P = 0.1430) for p53 Arg72Pro polymorphism between the two groups. We found a significant association between the heterozygous and ...
متن کاملcodon 72 polymorphism of p53 gene and hematologic manifestations in patients with systemic lupus erythematosus
background: systemic lupus erythematosus is a systemic autoimmune disorder with unclear etiology. the importance of some genes in the development of systemic lupus erythematosus has been implicated. the gene polymorphism in codon 72 has attracted a lot of attention and its role in the occurrence or progression of many cancers and autoimmune diseases especially systemic lupus erythematosus has b...
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ژورنال
عنوان ژورنال: Genetics and Molecular Research
سال: 2017
ISSN: 1676-5680
DOI: 10.4238/gmr16039721